Brown 1 pound ground beef in a large skillet over medium heat.
Break it into small pieces as it cooks.
Cook until no pink remains, about 6 to 8 minutes.
Drain the extra grease from the skillet.
Lower the heat to medium-low.
Place 16 ounces cubed Velveeta in the skillet.
Pour in 1 undrained 10-ounce can of Rotel.
Stir in 4 ounces cubed cream cheese.
Sprinkle in chili powder, garlic powder, onion powder, and black pepper.
Stir often until the cheeses melt, about 5 to 7 minutes.
Reduce heat to low and serve warm with tortilla chips.
Top with sliced green onions, jalapeños, or cilantro, if desired.